World’s Only Large-Scale Docetaxel Supplier Unreliant on Plantation-Derived Extracts

Docetaxel (sold under trade name Taxotere) is a very effective plant-derived chemotherapy drug used to treat various cancers, including breast, lung, prostate, gastric, head and neck, and ovarian cancer.

At Phyton, we use paclitaxel and an array of primary taxanes produced in-house using our proprietary Plant Cell Fermentation (PCF®) Technology and a patented semi-synthetic production process to manufacture high-quality docetaxel API that meets USP/EP compendia. Please click here to view the Docetaxel safety data sheet.

Formula: C43 H53 NO14
CAS Number: 114977-28-5
Chemical Name: Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-;(2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate

Phyton has a nearly 10-year track record of producing API-grade docetaxel on a large scale. Our Canadian cGMP facility has the capacity to supply nearly 150 kg of docetaxel API per year.

Phyton is the only large-scale docetaxel supplier in the world that controls the entire upstream and downstream docetaxel production process internally under strict GMP conditions. These controls, along with our scale, bring our customers North American/European quality and reliability at competitive prices.

Our docetaxel is produced from an intermediate derived naturally by cells cultured under cGMP conditions, providing a safe and dependable supply of finished API product that meets USP and and EP standards. Because our docetaxel is produced entirely within a contained environment, it is not subject to changes in the supply of biomass or 10-DAB resulting from climate, seasonality, price competition, disease, or political restrictions. We have full control of our supply chain.

Environmental Sustainability
Phyton is the world’s only supplier that produces docetaxel API without relying on 10-deaceytlbaccatin III (10-DAB), an extract derived from yew trees, which are vulnerable to harvesting and supply issues.