Phyton Biotech Receives Patent for the Production of Ingenol-3-angelate, Using Plant Cell Fermentation (PCF®)

Phyton Biotech is pleased to announce that we have been granted a new patent to cover the production of Ingenol-3-angelate, Ingenol and other Ingenol esters by using our proprietary Plant Cell Fermentation PCF® technology to culture plant cells from the plant family Euphorbiaceae. The patent was granted by the United States Patent and Trade Mark Office, and its US patent number is 10,172,306.  It will remain in place until March 18, 2036.

Ingenol-3-angelate, Ingenol and other Ingenol esters have been sought after for their activation of protein kinase C, as well as their anti-carcinogenic and anti-viral benefits. Some of the compounds have been noted for their potential therapeutic use, such as for the treatment of skin cancers.


Ingenol-3-angelate Production and Supply

In other methods, Ingenol-3-angelate has been sourced directly from plants of the Euphorbiaceae family. However, only low yields of the compound can be extracted from the milky sap of the Euphorbia peplus.

The alternative method that Phyton Biotech has invented and has been granted a US patent for comprises generation and use of plant cell cultures that are capable of producing Ingenol-3-angelate at a higher yield thus removing the uncertainty of relying on plantations or the use of wild plant materials. This is another exciting example of how our PCF® technology offers a “greener” and more sustainable manufacturing solution for the production of high-value compounds.

About Plant Cell Fermentation (PCF®)

PCF® promotes the natural processes of plant cell growth and biosynthetic pathway expression ex planta, in a controlled and fully defined fermentation environment.

Phyton Biotech’s expertise in developing difficult-to-make secondary metabolites was best exemplified when our team revolutionized the manufacturing process for Paclitaxel (an important anti-cancer API) using PCF®. This method is now recognized as the most sustainable and environmentally responsible approach for producing Paclitaxel, while also offering superior quality, reliability, environmental sustainability and cost advantages that other methods cannot.

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